Abstract: Objective: Chronic kidney disease (CKD) is a general term for heterogeneous disorders affecting kidney structure and function. Many studies have been done on correlating sonographic renal changes with renal function by using serum creatinine as a functional mark of renal failure but less is reported on correlation of eGFR with sonographic findings. The aim of this study was to determine the role of renal biometry in predicting renal function among patients with chronic kidney disease (CKD). Method: This was a hospital based cross-sectional study which evaluated 145 patients with CKD at Muhimbili National Hospital. All patients underwent both kidney sonography and renal function test based on estimated glomerular filtration rate (eGFR). Renal volume was compared to eGFR by using correlation and Likelihood Ratio. Results: Almost half of the patients with CKD had renal cortical volume below the normal health adult average. About twelve percent (12.4%) of patients had above normal cortical volume average however this was among patients with HIV nephropathy. Pearson correlation coefficient revealed positive relationship as right and left renal cortical volume and eGFR of (r ≈ +0.49 (p < 0.001); and r ≈ +0.43 (p < 0.001). Despite significant p-values, Pearson coefficient ranged between +0.7 and +0.3 defining a weak linear association between eGFR and renal cortical volume. Conclusions: Renal cortical volume is a weak biomarker in predicting renal function in patients with CKD.
Keywords: CKD, Ultrasonography, renal biometry, cortical volume, eGFR.
Title: RENAL CORTICAL VOLUME IN PATIENTS WITH CHRONIC KIDNEY DISEASE AT MUHIMBILI NATIONAL HOSPITAL, TANZANIA
Author: Mboka Jacob, Joel J. Bwemelo, Ramadhan Kazema
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
Research Publish Journals
