Abstract: Phytochemical analysis of Balanites aegyptiaca showed that it rich with active biological ingredients such as cumarins, flavonoids and steroidal saponins. The aim of this work is to evaluate the potential of Balanites aegyptiaca extract to attenuate oxidative stress and diabetic nephropathy in rats.
Methods: Male albino rats were divided into 6 groups (each 10 rats): control rats (group1) , animals in groups (2-6) were injected i.p with a single dose of streptozocin (STZ), then divided into untreated diabetic rats (group 2) , diabetic treated with 0.45 mg/kg Jnuvia (group 3 as positive control) and animals in groups (4-6) diabetic treated with Balanites aegyptiaca at different doses 600,800 and 1000 mg/kg b.w daily by intragastric administration for 12 weeks starting from day after STZ administration.
Results: Data obtained showed that Balanites aegyptiaca at concentration 800 mg/kg b.w protected against oxidative damage caused by STZ as indicated by lowering of serum glucose, creatinine, tissue lipid peroxide and elevation the antioxidant enzymes activities.
Conclusion: It was concluded that, the protective effect of Balanites aegyptiaca may be its high contents of polyphenols and curamins. For this it can be used as complementary natural ant diabetic agent to prevent diabetic complications.
Keywords: Diabetes mellitus- Nephropathy- Balanites aegyptiaca.
Title: Role of Balanites Aegyptiaca in Attenuation of Diabetic Nephropathy
Author: Safaa Y. Qusti, Regayah Y Sharahili, Said S Moselhy
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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