Abstract: Itterleukin-6 is a cytokine with an extensive range of biological activities. On the immune system it has the wide range of impact and it can affect the homeostatic process by having hormone like characteristics. It is widely used in the clinical intervention because it has both anti and pro-inflammatory properties. It is activated during inflammation and maturation of B cells. It can act as pyrogen and can cause fever during infection, non-infection and autoimmune diseases. IL-6 is produced by the macrophages and monocytes in reaction to other inflammatory cytokines which contain tumor necrosis factor (TNF)-beta and interleukin-11. In resting phase the receptors of IL-6 is present on normal activated B-cells, cells in hepatic and myeloid cell lines and normal T-lymphocytes. In the host defense the acute IL-6 expression plays a main role by activates the different cell population. IL-6 initiates the wide range of acute-phase proteins such as serum amyloid A (SAA), fibrinogen, hatoglobin, C-reactive protein, hepcidin and antichymotrypsin when acting on hepatocytes and lessend the cytochrome P450, transferrin, fibronectin and albumin, its structure contains the IL-6R, Sil-6R and gp130.it has role in many diseases but major role is present in the caner.
Keywords: IL-6, structure of IL-6, signaling of IL-6, role of IL-6 in diseses, IL-6 and cancer.
Title: Role of interleukin-6 in immunity: A Review
Author: Sana Naseem, Dr. Razia Iqbal, Talhat munir
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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