Abstract: This study was aimed to focus on reviewing the evidence and discussing the interaction roles of Vitamin D on the autoimmune disease, we intended to overview most common systemic autoimmune diseases and we excluded specific organ autoimmune disease. Comprehensive dilated search was performed of the literature through several medical science databases; MIDLINE (PubMed), Embase, for relevant studies which published in English up to December, 30. 2016 with human subjects. several Mesh terms were used in search methods among databases which are: “Vitamin D” AND “Autoimmune diseases” combined with “Systemic lupus erythematosus” AND “Rheumatoid arthritis” AND “Multiple sclerosis”. Studies references in the identified articles were searched for more relative studies to be included in our review. Epidemiological, genetic, and standard studies suggest a potential function of vitamin D in the pathogenesis of specific autoimmune diseases, the majority of which show a connection in between low levels of vitamin D and disease appearance or manifestations of these disease. Vitamin D has important functions beyond those of calcium and bone homeostasis which include modulation of the innate and adaptive immune responses.
Keywords: Autoimmune Diseases Flares, Systemic lupus erythematosus.
Title: Role of vitamin D deficiency on Autoimmune Diseases Flares
Author: Dr. Zainab Mousa Al. Nemer, Dr. Layla Hassan Al. Nosair, Dr. Thara Alawi Al. Sharfa, Dr. Zainab Zaki Al. Jaffer
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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