Abstract: The discovery that oxidative stress plays a central role in the development and progression of Diabetes along with its complications is well established. Diabetes, group of disorders attributed to hyperglycaemia with abnormal lipid metabolism remains one of the leading cause of mortality throughout the world. Vitamin E is undoubtly an effective antioxidant which assist the body in scavenging free radicals thereby alleviating oxidative stress. The present study aimed to evaluate the serum levels of vitamin E in Streptozocin induced Diabetic Albino rats treated with watermelon methanolic seed extracts. In this study, twenty five albino rats weighing averagely 150g were randomly divided into five groups of five rat each (n=5). Group A= Non Diabetic control; Group B= Diabetic control; Group C, D and E = Diabetic treated with 50mg, 100mg and 200mg of watermelon seed extracts respectively. The rats were housed in a healthy condition for a period of a week to acclimatize before the commencement of the experiments, food and water ad libitum. Diabetes was induced by single intraperitonial injection of 60mglkg body weight. Vitamin E levels were determined using method Neil and Pearson (1967) after 28 day treatment. The results indicates that serum vitamin E were significantly reduced (P<0.005) in diabetic group when compared to those treated with (100mg, 200mg of extracts) and control group. In conclusion, there were significantly lower serum vitamin E levels in streptozocin induced diabetic rats, a signal that diabetics are more prone to oxidative stress.
Keywords: Diabetes, Vitamin E, Watermelon seed extract Free radicals, Antioxidants.
Title: Serum levels of Vitamin E in Streptozin-Induced Diabetic Rats Treated with Watermelon Methanolic Seed Extracts
Author: Muhammad, Y., Zainab, A.D., Bukoye, A. O, Ibrahim, M.K, U. Wali, Yeldu, M.H, Muhammad, Y., Ahmad, MB
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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