Abstract: TGF-beta has been described as a surely understood controller of hematopoiesis through point by point investigations of hematopoietic begetters in vitro. A moderately late itemized audit depicts how TGF-beta manages multiplication and separation of hematopoietic forerunners in vitro, frequently as a negative controller of expansion. In this survey, we will examine how different Smad flagging pathways (TGF-beta, bone morphogenetic protein (BMP), activin) direct hematopoiesis, Smad flagging takes an interest in the determination or generation of hematopoietic stem cells (HSCs) amid improvement and keeps on managing the fate of HSCs and their progeny after their generation during development and postnatally. We have conducted a literature review in all studies that are with concern with this topic, to be able to summarize the main point in Smad signaling pathways in hematopoietic stem cells.
Keywords: Smad, TGF-beta, hematopoietic, investigations, multiplication, stem cells.
Title: Smad Signaling In Hematopoietic Stem Cell Biology
Author: Ahmed Maeesh AlQurashi, Ahmed Abdullah Alsheri, Abdulelah Faisal Alzahrani
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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