Steroid Response Pattern Among Childhood Idiopathic Nephrotic Syndrome, Systematic Review

Abstract: Background: Nephrotic syndrome (NS) is an important chronic disease in children. Approximately 90% of children with nephrotic syndrome have idiopathic nephrotic syndrome (INS), and the remaining 10% have secondary NS. Objective: aims to determine and evaluate the steroid responsiveness pattern and outcome of paediatric idiopathic nephrotic syndrome Methodology: We conducted a systematic review study that identified most of based evidenced trials which were evaluating or determine corticosteroid agents in steroid responsive in children with nephrotic syndrome (SRNS) from Medline, Embase, and the Cochrane Controlled Trials Register to the time of july 2016. Conclusion: our study showed higher incidents of steroid resistance in girls than boys. Although the frequency of progression to ESRD and mortality in girls was higher than boys, it was not statistically significant. Keywords: Nephrotic syndrome (NS), idiopathic nephrotic syndrome (INS), SRNS. Title: Steroid Response Pattern Among Childhood Idiopathic Nephrotic Syndrome, Systematic Review Author: Talal Khalid O Alafif, Naif Misfer J Alzhrany, Atif Mohammed A Hakami, Sahar Surour B Hussien International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Research Publish Journals

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