Abstract: The development of in vitro models of toxicity is required to decrease the dependence on potentially misleading in vivo animal studies. Research suggests that for certain systems, animal models are insufficient for toxicology testing. It is tedious to study all the functions of the liver in vivo, because of other organs interventions. Hence, the hepatocytes were cultured in vitro in order to study the different activities of the liver. Cadmium is one of the heavy metals which have toxic effects on the various organs and systems of the body. This paper evaluates whether cadmium induces alterations in the activity of alkaline phosphatase (AKP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) changes in chicken hepatocytes. The obtained results indicate that cadmium induced hepatocyte proliferation at different concentrations.
Keywords: Hepatocytes, Cadmium, Aspartate transferase, Alanine transferase, Alkaline phosphatase, Trypan blue dye.
Title: Stress induced biochemical analysis of hepatocyte proliferation in Chicken
Author: Aashoqullah Sajaad
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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