Abstract: Neonatal sepsis is one of the most important causes of morbidity and mortality throughout the world. The diagnosis of neonatal sepsis is notoriously difficult due to non-specific signs and symptoms. Currently, no specific biomarker can be considered as an ideal for diagnosis of sepsis in neonates. Therefore, this study has undertaken with aims to determine the utility of plasma NGAL among new biomarkers of sepsis. Out of 140 neonates included in this study, 70 were with suspected sepsis (as study group) and 70 were healthy controls. Mean level of NGAL in study group is 158 ± 79.35 pg/mL, which was statistically highly significant (p value=0.000) than control 77± 64.77 pg/mL. Study group further categorised as early onset (n=27) and late onset (n=43) of disease course. Mean level of NGAL in late onset sepsis group was noted high (170± 79.29 pg/mL) than that of early onset sepsis (141.8 ± 142.25 pg/mL). Blood culture report data was obtained and showed positive blood culture reports in 29 patients while negative blood culture reports in 41 patients. Raised values of NGAL seen in sepsis with positive blood culture (177± 85.05 pg/mL) than sepsis with negative blood culture (150 ± 76.71 pg/mL). Our findings support NGAL as a new promising biomarker helping paediatrician for diagnosis of the neonatal sepsis.
Keywords: NGAL-Neutrophil Gelatinase Associated Lipocalin, Neonatal sepsis.
Title: Study of Neutrophil Gelatinase Associated Lipocalin in Neonatal Sepsis
Author: Mrs.Vaishali S. Bhandare, Dr.P.E.Jagtap, Dr. S.P. Dhonde, Dr.G.J.Belwalkar, Dr. N.S. Nagane, Dr.V.V. Shiralkar, Mr.K.Suryawanshi, Mr.V.Mane
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
Research Publish Journals
