Abstract: Chronic Kidney Disease (CKD) is associated with high incidence of morbidity and mortality. The imbalance between oxidants and antioxidants is thought to play an important role in the tissue damage in CRF. The objective is to evaluate oxidant and antioxidant imbalance in CRF patients
Methods: A total number of 80 subjects comprising of 40 healthy controls and 40 Chronic Kidney Disease patients attending dialysis unit before dialysis were studied. In all the subjects, serum levels of malondialdehyde (MDA) as a biomarker of lipid peroxidation and antioxidant whole blood reduced glutathione (GSH) were estimated.
Results: The level of whole blood reduced glutathione was significantly decreased in CKD Patients when compared to healthy controls. Serum MDA was significantly increased in CKD patients when compared to controls.
Conclusion: The presence of increased systemic oxidative stress in chronic kidney disease patients seems to be associated with accumulation of uremic toxins, increased gycation end products and increased homocysteine level. The decrease in antioxidants levels appears to be mainly a consequence of increased oxidative stress. This suggests that oxidative stress is likely to be involved in the tissue damage in CKD patients.
Keywords: Oxidative stress, Antioxidants, CKD, Whole blood reduced glutathione, MDA.
Title: Study of serum Malondialdehyde and Whole Blood Reduced Glutathione in Chronic Kidney Disease
Author: Satishkumar D, Nagaraj R S, V Vishali
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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