Abstract: Staphylococcus aureus is a major pathogen causing a variety of infections ranging from mild skin infections to life threatening systemic illness. Antibiotic resistance by Methicillin Resistant Staphylococcus Aureus (MRSA) has grown to be common, and resistant to almost all antibiotics. The objective of the study was to see the antimicrobial susceptibility pattern of S. aureus isolates from different clinical samples against various brands of penicillins in Ebonyi State Teaching Hospitals of Abakaliki, Ebonyi State, Nigeria. A cross-sectional study was conducted from September to October 2008 among patients attending Ebonyi State Teaching Hospital, Abakaliki, Nigeria. A total of 200 Staphylococcus aureus isolates were obtained from patients with infections. They were cultured on mannitol salt agar media, a selective medium for S. aureus. Isolated strains of S. aureus were tested for antibiotic susceptibility patterns using standard disc diffusion technique and interpretation was done based on Clinical and Laboratory Standard Institute criteria.The resistance patterns of this isolates were ranked in decreasing order: penicillin V (81%), Ampicillin (63%), Amoxycillin (56%), Ampiclox (30%), Flucloxacillin (20%) and Cloxacillin (18%). It was observed that Cloxacillin, Flucloxacillin and Ampiclox showed better sensitivity patterns, the incorporation of beta lactam inhibitors like clavulanic acid present in these antibiotics have made them more effective.The rate of antimicrobial resistance is to conventional antibiotics is very high, continuous surveillance on antimicrobial susceptibility testing of S. aureus is essential for the detection of emerged resistant strains of S. aureus especially MRSA.
Keywords: S. aureus, MRSA, Resistance, Penicillins.
Title: Susceptibility Patterns of Staphylococcus Aureus Isolates from Clinical Specimens to the Penicillin’s
Author: Oluwakayode Temitope Adekunle, Olufunke Bolatito Shittu, Babatunde Lateef Alabi, Ogunbola Omolabake Ogunfolakan, Oguntola Ogundare
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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