Synergetic Effect of Green Tea Catechins in Presence of Metal Ions

Seema Verma, Prateek Pandya, Neelima Gupta

Abstract: Preventive and therapeutic activity of green tea is well known, the reports pertaining to the synergetic effect of its constituent polyphenolic catechins are of current interest to many, such as chemists, biologists, scientists from pharma industry, naturopathy, etc. Present report describes the results from an experimental investigation about the effect of two metal ions - Al(III) and Fe(II) on binding affinity of two catechin compounds, (–)-epigallocatechin (EGC) and (–)-epigallocatechin gallate (EGCG) with bovine serum albumin (BSA) and  calf thymus 2- deoxyribonucleic acid(CT-DNA) using UV-visible spectroscopic method. Calculated Binding constant values indicate that the interaction of EGCG and EGC with BSA increases significantly for each metal-catechin conjugates.

Keywords: Green tea catechins, EGCG, EGC, BSA, Binding constant, UV-titration.

Title: Synergetic Effect of Green Tea Catechins in Presence of Metal Ions

Author: Seema Verma, Prateek Pandya, Neelima Gupta

International Journal of Interdisciplinary Research and Innovations

ISSN 2348-1218 (print), ISSN 2348-1226 (online)

Research Publish Journals

Vol. 7, Issue 2, April 2019 – June 2019

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Synergetic Effect of Green Tea Catechins in Presence of Metal Ions by Seema Verma, Prateek Pandya, Neelima Gupta