Abstract: Mixed ligand metal complexes of Sulfadoxin eand pyrimethamine such as [Cu(sul)(pym)Cl]Cl. 2H2O, [Zn(sul(pym)Cl]Cl.2H2O, [Ni(sul)(pym)Cl]Cl.6H2O and [Fe(sul(pym)Cl3].6H2O. have been synthesized and characterised by elemental analysis, IR ,UV-Visibe, ESR, NMR,XRD spectrscopic techniques. Thermal analysis was studied by TGA, DSC method. Morphological studies were carried out by scanning electron microscopic method. DNA binding studies was carried out by cyclicvoltammetric method. From the spectral studies a square planar geometry was proposed for the copper complex. In conclusion, prepared complexes showed enhanced DNA binding tendency than the parent drug that might be of interest for future research.
Keywords: Metal complexes. ligands, cyclic voltammetric method, DNA binding.
Title: SYNTHESIS, CHARACTERISATION AND DNA BINDING STUDY OF MIXED LIGAND METAL COMPLEXES OF SULPHADOXINE & PYRIMETHAMINE
Author: Dr. S. Pushpa Latha
International Journal of Interdisciplinary Research and Innovations
ISSN 2348-1218 (print), ISSN 2348-1226 (online)
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