SYNTHESIS, STRUCTURE-PARAMETER CORRELATION AND ANTIMICROBIAL EVOLUATION OF 1-(4-ISOBUTYLPHENYL) -3-PHENYL-2-PROPENONE COMPOUNDS

Abstract: A series of 1-(4-isobutylphenyl)-3-phenyl-2-propenone compounds are synthesized from 4-isobutyl acetophenone with various substituted benzaldehydes by crossed aldol condensation. The synthesized compounds are characterized by their physical constants and spectral data. Antibacterial and anti fungal activities of synthesized 1-(4-isobutylphenyl)-3-phenyl-2-propenone compounds are measured by Kirby-Bauer disc diffusion method. The bacterial strains used are gram positive bacteria Bacillus subtilis, M.luteus and S.aureus gram negative bacteria Escherichia coli, P.aeruginosa and k.pneumonia and anti-fungal studies with Aspergillus niger, Tricoderma viride and Mucor species. Keywords: Crossed-Aldol condensation; Thionyl chloride /Ethanol; 1-(4-isobutylphenyl)-3-phenyl-2-propenone compounds; Substituent effects; Antimicrobial activities. Title: SYNTHESIS, STRUCTURE-PARAMETER CORRELATION AND ANTIMICROBIAL EVOLUATION OF 1-(4-ISOBUTYLPHENYL) -3-PHENYL-2-PROPENONE COMPOUNDS Author: C.Balamurugan, D.Kamalakkannan, R.Suresh, S.P.Sakthinathan, G.Vanangamudi, G.Thirunarayananb International Journal of Life Sciences Research ISSN 2348-3148 (online), ISSN 2348-313X (Print) Research Publish Journals

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