Systematic Review of Sensitive Biomarkers of Graves’ Disease

Abstract: Graves’ disease (GD) is an autoimmune disorder, which is brought on by unusual hereditary changes, consisting of modifications in the expression levels of specific human cellular genes, and different ecological aspects, such as smoking cigarettes. This systematic review study was aimed to determine the most sensitive biomarkers used to predict and diagnosis of GD through a evidence based studies. We conducted electronic bibliographic research independently according to the validated methods of the Preferred Reporting Items for Systematic Reviews (20¬) using the following databases: Medline, Embase, Web of Science, and The Cochrane Library. The database search (date range, 1970–2016) was performed using the following MeSH search terms: ‘‘Graves’ disease,’’ ‘‘toxic goiter,’’ and ‘‘biomarker.’’ interleukin-2, interleukin-10, genetic polymorphism. Direct proof revealed that OPN may cause distinction of Th17 cells in the peripheral blood and thyroid glands or draw in Th17 migration to thyroid glands of GD patients. The relationships in between OPN and CCL20/CCR6/Th17 axis in GD still have to be examined. Keywords: Graves’ disease (GD), Sensitive Biomarkers. Title: Systematic Review of Sensitive Biomarkers of Graves’ Disease Author: ALANAZI, ABDULLAH MOFAREH M, ALANAZI, MUNEEF SUWAILEM A, ALSHAMMARI, BADER OBAID K, ALMATRAFI, ABDULAZIZ RAMDAN H, ALENEZI, ABDULLAH MUNIF, ALANAZI THAMER THEYAB M., ALANAZI, NASSER SALEM M International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Research Publish Journals

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