Abstract: The risk factors of head and neck squamous cell carcinoma. head and neck squamous cell carcinoma (HNSCC) happen to be one of the more common cancers all over the world. Of all head and neck cancers, 90% of them start in squamous cells. It has been researched that there are several risk factors that play a part in developing head and neck squamous cell carcinoma (HNSCC). The purpose of this systematic review is to determine the risk factors of head and neck squamous cell carcinoma. The method of writing this article is systematic review, where the articles were published from 2012 to 2020 that focused on assessing the risk factors of head and neck squamous cell carcinoma. Assessment of the methodological quality of each article was carried out using PRISMA checklist. The results of the analysis of head and neck squamous cell carcinoma risk factors are alcohol (p value = 0.001), HPV in the Oral cavity (p value = 0.0005), HPV in the Hypopharynx ( p value = 0.0005), HPV in the Oropharynx (p value = 0.0001), HPV in the Larynx (p value = 0.0001), < 5 missing teeth (p value = 0.001), Annual dentist visit (p value = 0.001), Daily tooth brushing (p value = 0.001), Gum disease (p value = 0.001), Betel nut chewing by people 16–30 years (p value = 0.000), betel nut chewing by people >30 years (p value = 0.000), people 16–30 years (p value = 0.000), Male population who smokes ( p value = 0.001), Former smokers (p value = 0.001) and Current smokers (p value = 0.001). To conclude, after reviewing the studies and obtaining the results and discussing and understanding them, in this systematic review it can be said that the risk factors that have a significant association with patients that have head and neck squamous cell carcinoma.
Keywords: Head and Neck Squamous Cell Carcinoma, Risk Factors, HNSCC, Risk Factors.
Title: SYSTEMATIC REVIEW: THE RISK FACTORS OF HEAD AND NECK SQUAMOUS CELL CARCINOMA
Author: Nadia Rachel Rajaratnam Peter, Ida Bagus Tjakra Wibawa Manuaba, INW Steven Christian, Putu Anda Tusta Adiputra
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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