Abstract: Systemic lupus erythematosus (SLE) is an auto-immune inflammatory illness credited to environmental and genetic factors causing the dysfunction of T cells, B cells, and dendritic cells and the production of antinuclear autoantibodies that affects multiple systems of the body. This study was aimed to overview the prevalence and characteristics and therapeutic management of the Systemic lupus erythematosus (SLE). MEDLINE (via PubMed), EMBASE, and the Cochrane Library were searched on 29 November 2016, using search terms (Medical Subject Heading [MeSH], EMTREE, and/or free text) from three categories: 1) systemic lupus erythematosus (lupus erythematosus, systemic, systemic lupus erythematosus, lupus, SLE); 2) prevalence, disease characteristics, management, and outcomes (characteristic*, disease attributes, flare*, guideline*, health care need, health planning guidelines, health services needs and demand, management, mortality, needs assessment, patient care, practice guideline, prevalence, population characteristics, quality of life, recommendation*, remission, remission induction, therap*, and treatment. The pathogenesis of SLE is Numerous genes provide vulnerability to disease development. Interaction of sex, hormonal milieu, the HPA axis, and malfunctioning immune guideline, such as clearance of immune complexes and apoptotic cells, modify this vulnerability. The loss of immune tolerance, increased antigenic load, excess T cell aid, defective B cell suppression, and moving of Th1 to Th2 immune responses cause cytokine imbalance, B cell hyperactivity, and the production of pathogenic autoantibodies. Lupus continues to present many unanswered questions.
Keywords: Systemic Lupus Erythematosus.
Title: Systemic Lupus Erythematosus (SLE), prevalence, disease characteristics and treatment options: Systematic review
Author: Ammar Mohammed Afif Alhaqli, Mahmood Abdullrahman Najmi, Ammar yasser shanou , Mohammed Salem A Alqurashi, Abdulrahman Ali J Walibi, Arwa meshal alshaikh, Jumana ahmed jabber, Abdolmalek mohammad alghamdi
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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