Abstract: The present study is aimed to investigate the toxic effects of synthetic azo dye, tartrazine on reproductive toxicity in male adult rats. The rats were administered with tartrazine at doses of 100mg/kg bwt, 300 mg/kg bwt and 500 mg/kg bwt for 60 days. The body weights and weights of reproductive organs decreased in tartrazine administered groups as compared to control group. Results also revealed significant decrease in sperm parameters in tartrazine administered animals over controls. The circulatory level of testosterone was significantly low with increased activity levels of LH and FSH in tartrazine treated rats as compared to controls. Activity levels of the antioxidant enzymes, SOD, CAT, GR and Gpx were significantly reduced with increased activity levels of Lpx in epidydimis and testis of tartrazine treated groups. The results of the present study concluded that tartrazine reduces testosterone and induces oxidative stress in testis thereby suppressed reproduction in adult male rats.
Keywords: Tartrazine, male reproduction, testosterone, oxidative stress, rat.
Title: Tartrazine, a male reproductive supressor in adult albino rats
Author: A.Meghapriya, B.Kishori
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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