Abstract: Background: Obesity is a chronic low grade inflammatory state associated with the development of insulin resistance, type 2 diabetes mellitus and atherosclerosis. TNF and Interleukin 6 are proinflammatory cytokines which relate starting of immune response.
The aim of the study: Relationship between TNF and Interleukin 6 in people with and without metabolic syndrome.
Materials and methods: The study involved 131 healthy individuals aged 25-55 years old randomly chosen in Tirana. Data concerning generalities, sex, residence, age, weight, height, abdominal circumference, systolic blood pressure, diastolic blood pressure , pulse, BMI, cholesterol, triglycerides, LDL, HDL, glycemia, TNF , interleukin 6 , insulinemia and HOMA-IR were collected. Insulin resistance and insulin sensitivity were calculated and compared within people with and without MS. MS prevalence was determined according IDF criteria.
Results: We found in people with and without MS significant difference between Interleukin 6 levels (P 0,01) and between TNF alpha levels (P<001).
In subjects with MS we observed an important correlation between interleukin 6 and insulinemia (p=0.029, r=0.292 )and between TNF and total cholesterol (p=0.001, r=0.315 ). Also a significative correlation was noticed between Homa-IR and TG in the MS population (p=0.001, r=0.489).
Conclusions: According our results metabolic syndrome subjects have a higher inflammatory state compared to the healthy population. The results show a strong correlation of pro inflammatory cytokines levels with insulinemia, triglycerides and cholesterolemia suggesting an important role of pro inflammatory cytokines in the metabolic syndrome pathogenesis.
Keywords: MS – metabolic syndrome IDF – International Diabetes Federation.
Title: The connection between TNF and IL-6 in persons with and without metabolic syndrome
Author: Violeta Hoxha , Dorina Ylli , Gerond Husi , Thanas Furreraj , Zamira Ylli , Pranvera Doci , Eni Celo , Elizana Petrela , Marjeta Kermaj , Agron Ylli
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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