Abstract: The ovaries stops producing estrogen during menopause which turns out to have an effect on various organ functions and the body's metabolism, including lipid oxidation. Previous studies have shown that when examining the levels of Malondialdehyde (MDA) in women who have reached the age of menopause, an increase in MDA levels can usually be observed. One of the food ingredients that is rich in antioxidant is the skin of red dragon fruit (Hylocereus polyrhizus), so it is hoped that the skin of red dragon fruit can be a source of phytoestrogens that can play a role in improving MDA levels in menopausal women. This study aims to determine the effect of ethanol extract of red dragon fruit peels (Hylocereus polyrhizus) on the levels of Malondialdehyde in menopausal model rats. This study is a purely experimental study. A randomized post-test only control group design research was conducted on 30 female Wistar rats. The study sample was divided into the control group (P0), the ethanol extract of red dragon fruit peels at a dose of 60mg / 200grBB group (P1), and the ethanol extract of red dragon fruit peels dose 90mg / 200grBB group (P2). The highest MDA Plasma / mm level was found in group (P1), 2,789 µmol / L, followed by P2, 2,157 µmol / L and (P0) with a mean of 1,944 µmol / L. The results showed that there is no significant effect of ethanol extract from red dragon fruit peels on Malondialdehyde Levels in menopause model rats.
Keywords: Menopause, Malondialdehyde, Antioxidant, Red Dragon Fruit Peels, Hylocereus polyrhizus
Title: The Effect of Ethanol Extract from Red Dragon Fruit (Hylocereus polyrhizus) Peels on Malondialdehyde Levels in Menopause Model Rat
Author: Nur Aliyyah Binti Harun, I Wayan Sugiritama, IG Nyoman Sri Wiryawan
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
Research Publish Journals
