Abstract: The use of Allium Sativum (garlic) for the treatment of various microbial infections of the human body has been an age-long practice, however many bacterial organisms have developed resistance to most conventional antibiotic drugs. The aim of this study was to demonstrate the effectiveness of aqueous garlic extracts against bacterial keratitis caused by Staphylococcus aureus and Psuedomonas aeruginosa . The study was carried out both in vitro and in vivo. The in vitro study was carried out to measure zones of inhibition and the minimum inhibitory concentrations while the in vivo study was done to assess the effect of the extracts on the cornea. The data obtained were analysed using the Analysis of Variance at a significance level of P<0.05 and tested against the research hypothesis. The in vivo results showed that the aqueous garlic extracts were effective in treating the keratitis caused by the two microorganisms(p=0.00). 0.3% Ciprofloxacin eye drop was more effective in treating the microbial keratitis than the aqueous garlic extracts. The in vitro results showed that the micro organisms were sensitive to aqueous garlic extract and their sensitivity was concentration dependent. It is therefore safe to conclude that aqueous garlic extract is effective in treating bacterial keratitis.
Keywords: Allium Sativum, Bacterial Keratitis, Staphylococcus aureus, Pseudomonas aeruginosa.
Title: The Effects of Aqueous Extract of Garlic on Bacterial Keratitis
Author: Ibeje T., Ikoro N.C., Esenwah E.C., Megwas A.U., Azuamah Y., Eronini Y., Odikemere M.
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
Vol. 11, Issue 1, January 2023 - March 2023
Page No: 18-23
Research Publish Journals
Website: www.researchpublish.com
Published Date: 02-February-2023
