Abstract: The use of natural products as a means of treatments for many physiological threats such as diabetes is currently gaining momentum in Nigeria. Diabetes is a metabolic syndrome that afflicts an estimate of 143 million people and that oxidative stress plays a vital role in development of diabetic and its attendant complications. Malondialdehyde (MDA) a product of lipid peroxidation is a convenient marker for the assessment of oxidative stress.
Objective: The study was aimed at investigating the hypoglycaemic and antioxidants property of Watermelon (Citrullus lanatus) seed extracts on Streptozocin (STZ) induced diabetic rats.
Materials and Methods: A total of twenty five (25) rats were divided into five (5) groups of five (5) rats each; Non- Diabetic Control, Diabetic Control and the Diabetic treated with 50mg, 100mg and 200mg concentration of seed extracts for a period of four weeks. Diabetes was induced by a single intraperitonial injection of freshly prepared STZ (60mg/kg b.w). Fasting blood glucose was monitored on weekly basis using Fine test Auto coding glucometer. On the 29th day of treatment, the rats were sacrificed under Diethyl ether anaesthesia and the blood was collected directly from heart. Fasting blood sugar was measured weekly and after sacrifice in addition to MDA and were statistically analysed..
Results: The results showed that Citrullus lanatus seed extract at dose of 200mg can reduce serum glucose significantly (P<0.05) from 19.1±3.9 mmol/l (343.5 ± 69.7 mg/dl) to 13.1 ±1.2 mmol/l (235.9±22.4 mg/dl). Serum MDA of Diabetic control (3.3±0.6 µmol/l) was significantly (P<0.05) higher than that of Diabetes (xx µmol/l) treated with 200mg (2.1±0.4 nmol/dl) of seed extracts. Citrullus lanatus seed extract therefore prove to have hypoglycaemic and antioxidant properties.
Keywords: Diabetes, Citrullus lanatus, Glucose, MDA, Oxidative Stress.
Title: The Effects of Citrullus lanatus Seed Extracts on Malondialdehyde and Serum Glucose in Streptozocin Induced Diabetic Rats.
Author: Muhammad, Y., Abubakar, N., Musa, M.S., Wali, U., Yeldu, M.H., Ahmed, A.Y., Ngaski, A.A., Ahmad, M.B. Saidu, A.Y, Gulumbe, N.S.
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
Research Publish Journals
