Abstract: Medicinal plants are the sources of many important scientific drugs of the modern world. The leaves of Carica Papaya were collected from Nsukka towns. Phytochemical studies were carried out on the crude aqueous leaf extract (decotion) using standard phytochemical methods. Blood samples from normal haemoglobin genotype homozygotes (HbAA), sickle heterozygotes (Hb AS) and sickle homozygotes (HbSS) of ages between 20 and 30 years collected from the University of Nigeria Teaching Hospital (UNTH), Enugu, were used for the study. The haemolytic activity of Carica Papaya aqueous extract was investigated using the normal haemoglobin genotype, sickle heterozygotes and sickle haemozygotes at different incubation period and at the different concentrations of the plant extract. The study of the haemolytic activity of Carica Papaya plant extract on different Hb-genotypes at different incubation periods showed heamolysis (invitro) significantly higher (p<0.05) in the genotype HbSS when compared to Hb AS and Hb AA individuals. The heamolysis observed in the Hb AS is significantly higher than that of Hb AA. The result of the study showed that Carica Papaya causes haemolysis which was more evident in genotype ‘SS’ due to the fragility and instability of sickle haemoglobin.
Keywords: Haemolysis, Genotype, phytochemical, Carica Papaya.
Title: The Haemolytic Effect of Aqueous Extract of Carica Papaya
Author: OBIEKWE UCHE WINIFRED, ALUMANAH EDWIN. O
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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