Abstract: The present research aimed to study the histological effect of Ibuprofenol on the liver as well as its effect on body weight. Twenty-four (24) rats of average weight of about 150g-240g were used in this study. They were separated into four groups labeled A, B, C and D. group A served as the control consisting of four rats while group B, C, D and E served as the control. The test groups where further divided into B1, B2, C1, C2, D1 and D2. The control group A was fed grower’s mash and water while the test groups B, C and D were orally administered various doses of 0.18ml, 0.32ml and 0.4ml/kg body weight for three weeks (acute) and six weeks (chronic) respectively. The rats were sacrificed and liver harvested for histological investigation. The results of this study showed that weight of the animal decreases in a dose-dependent fashion when compared with the control group which on the other hand showed significant increase in weight. The histochemistry analysis revealed that the liver of test animal in both acute and chronic phase showed damages ranging from reduced hepatocyte population, nuclear vacuolation, parenchyma vacuolation, pyknotic nuclei and tissue crevices. Considering the observed effects of Ibuprofen on the histology of the liver, it is recommended that its administration should be strongly regulated as it may cause cellular injuries to the liver. Furthermore, there is need for further research in this domain.
Keywords: Ibuprofen Dosage, animal decreases, hepatocyte population, nuclear vacuolation, parenchyma vacuolation.
Title: THE HISTOLOGICAL EFFECT OF IBUPROFEN DOSAGE ON THE LIVER OF WISTAR RATS
Author: Uwuigbe Mathew, Ohiwerei Wisdom Omogbai, Ehiremen Samuel Ehimare
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
Vol. 10, Issue 4, October 2022 - December 2022
Page No: 15-21
Research Publish Journals
Website: www.researchpublish.com
Published Date: 27-October-2022
