Abstract: Ghrelin is well known endogenous peptide. Its role in managing obesity and/or diabetes was not well defined.
Objective: To define the relationship of ghrelin with diabetes mellitus and/or obesity.
Methods: A comparison of four group of subjects had taken place. A control group composed of normal healthy subjects. The second, third and fourth group are diabetic non-obese subjects, obese non-diabetic subjects, and diabetic obese subjects.
All the patients are recruited from King Abdulaziz University Hospital. Blood samples had been taken from fasting patients measuring serum ghrelin, fasting blood glucose, insulin level, LDL-cholesterol, HDL-cholesterol, total cholesterol, triglyceride and haemoglobin A1C.
Results: The diabetes obese group was the most abundant with statistically significant correlations and most of the varibles were negatively correlated with serum ghrelin The values are successively -0.640, -0.322, 0.201, 0.068, 0.151, -0.694, -0.555, -0.529 for BMI, LDL-Cholesterol, HDL-Cholesterol, Total Cholesterol, Triglyceride, Fasting Blood Glucose, Hb A1C, andum Insulin
Conclusion: A negative relationship is concluded between serum ghrelin and BMI, FBG and serum insulin levels. This suggests suggest a suppressive controlling mechanism of ghrelin secretion in obese and diabetics.
No relationship can be established between ghrelin level and serum lipids
Keywords: Ghrelin, diabetes, patients, BMI, LDL-Cholesterol, HDL-Cholesterol, Total Cholesterol, Triglyceride, Fasting Blood Glucose, Hb A1C, andum Insulin.
Title: The Relationship of Ghrelin with Diabetes Mellitus and/or Obesity
Author: Khaled Saad Alzahrani, Wahbi Khalid Albishi, Hesham Abdulmalik Alshaikh, Abdullah Waheed Calacattawi, Samar Saud Alsifiri
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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