Abstract: We previously reported that pretreatment with Garcinia kola (GK) crude extract alleviated hyperthermia in colitis and improved intestinal antioxidant enzymes in both healthy and colitis male rats. The present study investigated the therapeutical effect of the extract on acute acetic acid induced ulcerative colitis in male wistar rats. 20 male wistar rats weighing 120g-150g were randomly divided into vehicle- treated, Garcinia kola, colitis and colitis treated groups. Acute colitis was induced with 1ml/200g of acetic acid and 150mg/kg (P.O) was administered once per day as previously reported. The result showed that treatment with GK did not prevent weight loss 5 days posttreatment. Significant increase (P<0.05) was noticed 14 days and 21 days posttreatment. When compared with colitis group, colitis treated group showed a significantly low (P<0.05) diarrhea and ulcer scores. Also, tissue thickness of colitis treated group was significantly reduced (P<0.05). Histological studies of the colon tissues of colitis treated rats revealed regenerating mucosal layer with numerous regenerating colonic crypts and a distinguishable colonic layers. The findings of this study suggest that GK exerted a therapeutical effect on acute acetic acid induced colitis in male wistar rats.
Keywords: Garcinia kola, colitis, acetic acid, colon, therapeutical, colon.
Title: Therapeutical Effect of Crude Extract of Garcinia Kola on Acetic Acid -Induced Ulcerative Colitis in Male Rats
Author: M.J. Adeniyi, S.F. Ige
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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