Abstract: Pesticides are being used to keep pests away from the crops. They kill the pests but also cause imbalance in ecosystem. Endosulfan was also used extensively in Indian agriculture as pesticide. The residues of endosulfan reach to water bodies mostly through agricultural runoff and causes severe damage to aquatic fauna predominantly to fishes. They come in direct exposure to this toxic chemical which has been implicated a gradual toxicity, neurotoxicity, hepatotoxicity, genotoxicity and various other biochemical alterations in fishes. Present study is designed to study the alterations in serum creatinine in the blood serum of Clarias batrachus on exposure to various concentration of endosulfan in a dose as well as duration dependent manner. After statistical analysis of the data, it has been observed that alterations caused in creatinine are highly significant (p>0.001). This may be due to deteriorating effects of endosulfan on glomerular fenestrae. The results indicate the nephrotoxic nature of endosulfan in fishes.
Keywords: Clarias batrachus, Endosulfan, Creatinine, Nephrotoxicity.
Title: Toxic Impact of Endosulfan on Serum Creatinine Level in Clarias batrachus: In vivo study
Author: Prakash Singh, Rizwan Ahmad, G.B. Chand
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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