Abstract: Toxicology is a discipline, overlapping with biology, chemistry, pharmacology, and medicine, that involves the study of the adverse effects of chemical substances on living organisms and the practice of diagnosing and treating exposures to toxins and toxicants. The relationship between dose and its effects on the exposed organism is of high significance in toxicology. Factors that influence toxicity includes the dosage, route of exposure, species, age, sex, and environment. The goal of toxicity assessment is to identify adverse effects of a substance. Adverse effects depend on two main factors: i) routes of exposure (oral, inhalation, or dermal) and ii) dose (duration and concentration of exposure). To explore dose, substances are tested in both acute and chronic models. Methanol is an industrial chemical used after 1800s. It is a toxic. This chemical are used to produce biodiesel and also used in ethanol manufacturing industries as a denaturant additive. Glutathione peroxidase is associated with insurance against oxidative pressure, and accordingly utilizes glutathione as a substrate. Glutathione likewise goes about as a substrate in other detoxifying proteins against oxidative pressure, for example, glutathione transferees. The present study has been undertaken to understand effect of Methanol on Superoxide Dismutase (SOD) activity on freshwater fish Cirrhinus mrigala.
Keywords: Methanol, Superoxide Dismutase, Cirrhinus mrigala.
Title: Toxicological studies of Methanol on Glutathione PeroXidase (GPx) activity of freshwater fish Cirrhinus mrigala
Author: MADHAV BHILAVE
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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