Abstract: Background: HbA1c is considered an indicator of average blood glucose concentrations during the preceding 2 to 3 months and, thus, a long-term marker of glucose homeostasis. Abnormalities may be a result of changes in insulin secretion and insulin-stimulated uptake of glucose in muscle and fat tissue.
Objective: Vitamin D deficiency is associated with a greater risk of developing type 2 diabetes mellitus (T2DM). Studies looking at the effect of vitamin D replacement on glycaemic control in type 2 diabetics are few and conflicting. So our objective come which was to test whether vitamin D level has any effect on HbA1c level concerning diabetes, and whether there are any changes in this correlation with age different.
Methodology: Participants were 299 diabetic patients divided to three groups according to their age 1) children which form almost 70% of participants; 2) adolescents which were 30% 3) adults which were only 1% of participants in this study. The data were recruited through outpatient departments of “King Abdul Aziz University Hospital in Jeddah Saudi Arabia. Fasting venous blood samples were collected by phlebotomy to perform HbA1c analyses by high-pressure liquid chromatography. Serum (s-25(OH) D) was measured using high-pressure liquid chromatography tandem mass spectrometry.
Results: the most effected among this population with vitamin D deficiency is the diabetic children 70% of children population showed good glycemic control. And 76% of adolescents with vitamin D deficiency also were in a good controlled (HbA1c ≤ 7 %) category.
Conclusion: this study revealed that vitamin D deficiency was higher in diabetic children compared to healthy controls. It will be of interest for future studies to investigate whether vitamin D supplementation will improve glycemic control and inflammation status in vitamin D deficient diabetic children.
Keywords: Vitamin D, Glycated Hemoglobin (HbA1c) level, high-pressure liquid chromatography.
Title: Vitamin D Effects on Glycated Haemoglobin (HbA1c) Level, and Their Correlation to Age
Author: Esraa mohiddin a. gadah, Daniyah salmeen s. baduqayl, Ahlam Omar a. albisaisi, Sara mohammedalbager m. Aljifri
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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