Abstract: Cigarette smoking is one of the major causes of mortality involving respiratory and cardiovascular illness in developing countries. Cigarette smoking is known to contain abundant of free radicals, which is able to cause tissue oxidative damage at various levels. The body has the ability to produce antioxidants. When there are excessive free radicals generated due to smoking, the available tissue antioxidants may become depleted, leading to oxidative stress. Male albino rats were induced with cigarette smoke for 70 days to assess the induced oxidative damage due to lung muscle atrophy. An enhanced lipid per-oxidation was recorded with elevated activity levels of conjucated diens, malondialdehyde and other thiobarbituric acid reactive substances (TABARS) in denervated muscle. The activity levels of antioxidant defense enzymes, viz. superoxide dismutase (SOD), catalase (CAT), glutathioneperoxidase (selenium, non-selenium) (GPx), glutathione reductase (GR), glutathione- s transferase (GST) were depleted in the cigarette smoke induced lung muscle. Vitamin E is a major antioxidant. When the Experimental control animal (cigarette smoke induced muscle) was supplemented with vitamin E, revealed a depleted lipid peroxidation and increased activity levels of antioxidant defense enzymes. In this study we investigate the efficacy of antioxidant, the supplementation of vitamin E could prevent the oxidative damage in the lung muscle despite smoking.
Keywords: Oxidative stress, cigarette smoke, Vitamin E, antioxidants
Title: Vitamin E Modulates the Oxidant –Antioxidant Imbalance during Cigarette Smoke Induced Oxidative Stress in Rats
Author: Dr. M. Sendhilvadivu
International Journal of Life Sciences Research, ISSN 2348-3148 (online)
ISSN 2348-313X (Print)
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